3-[[(2,6-二氟苯基)磺酰基]氨基]-2-氟苯甲酸甲酯

3-[[(2,6-二氟苯基)磺酰基]氨基]-2-氟苯甲酸甲酯 - Names and Identifiers

Name	Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate
Synonyms	DABRAFENIB INT Methyl 3-(2,6-difluorophenylsulfonaMido)-2-fluorobenzoate Methyl 3-{[(2,6-difluoropheyl)sulfonyl]aMino}-2-fluorabenzoate Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate Methyl 3-{[(2,6-difluorophenyl)sulfonyl]aMino}-2-fluorobenzoate methyl 3-(((2,6-difluorophenyl)sulfonyl)amino)-2-fluorobenzo... Benzoic acid, 3-[[(2,6-difluorophenyl)sulfonyl]amino]-2-fluoro-, methyl ester
CAS	1195768-19-4
EINECS	812-675-6

3-[[(2,6-二氟苯基)磺酰基]氨基]-2-氟苯甲酸甲酯 - Physico-chemical Properties

Molecular Formula	C14H10F3NO4S
Molar Mass	345.29
Density	1.507±0.06 g/cm3(Predicted)
Boling Point	445.4±55.0 °C(Predicted)
pKa	6.68±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature

3-[[(2,6-二氟苯基)磺酰基]氨基]-2-氟苯甲酸甲酯 - Introduction

Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate, also known as fluorobenzoic acid 2,6-difluorophenylsulfonamide Methyl ester, is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: colorless or light yellow liquid
-molecular formula: C13H9F3NO4S
-Molecular weight: 347.27g/mol
-Melting point: 52-54 ° C
-Boiling point: 315 ° C
-Density: 1.559g/cm3

Use:
Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate is commonly used as an important intermediate in organic synthesis, and is used to prepare compounds such as drugs, dyes and pesticides. It can be used as a sulfonamido protecting reagent, participate in the preparation of acid chlorides, and can be used for the protection of aromatic amines.

Preparation Method: The preparation method of
Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate is mainly carried out by the following steps:
1.2,6-difluorobenzoic acid reacts with thionyl chloride to generate 2,6-difluorophenyl sulfonyl chloride.
2.2,6-difluorophenyl sulfonyl chloride reacts with methanol to generate 2,6-difluorophenyl sulfonate methyl ester.
3. The Methyl 2,6-difluorophenyl sulfonate is reacted with Methyl aminofluorobenzoate to produce the final product Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate.

Safety Information:
The specific hazards and safety measures of Methyl 3-{[(2,6-difluoropheyl)sulfonyl]amino}-2-fluorabenzoate should be evaluated according to the specific application scenarios and conditions of the compound. Therefore, when using or handling this compound, please refer to the product's Safety Data Sheet (MSDS) and follow the appropriate safety practices. This can avoid potential hazards and injuries and ensure personal safety. If you come into contact with this compound, rinse immediately with plenty of water and seek medical assistance.

Last Update：2024-04-09 20:48:19